Extracapsular Spread in Melanoma Lymphadenopathy: Prognostic Implications, Classification, and Management
| Autor: | Howard Peach, Martin Heaton, Michelle C. I. Lo, D Dewar, Ryckie G. Wade, Marc Moncrieff, Alyss V. Robinson |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Melanoma Hazard ratio Sentinel lymph node Retrospective cohort study medicine.disease Gastroenterology 03 medical and health sciences 0302 clinical medicine Oncology Surgical oncology 030220 oncology & carcinogenesis Internal medicine Biopsy Medicine 030211 gastroenterology & hepatology Surgery Stage (cooking) business Survival rate |
| Zdroj: | Annals of Surgical Oncology. 28:1642-1653 |
| ISSN: | 1534-4681 1068-9265 |
| DOI: | 10.1245/s10434-020-09099-w |
| Popis: | Extracapsular spread (ECS) is recognized to be a high-risk factor in melanoma patients with macrometastatic (N+) nodal disease; however, ECS risk in sentinel lymph node (SLN) biopsy, micrometastatic stage III disease is ambiguous. The aim of this study was to examine ECS incidence and its prognostic significance. A two-center, retrospective analysis of all patients with micro/macrometastatic lymphadenopathy undergoing nodal surgery from 2008 to 2014 was performed. Patient demographics, tumor characteristics, nodal ECS status, and patient outcomes were collected. Overall, 515 patients with nodal disease were identified (males/females = 277/238); median age was 63 years (range 17–94). There was an increased frequency of ECS disease in N+ disease compared with SLN+ disease (52.4% vs. 16.2%; p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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