Basic Ionic Liquid Promoted Domino Knoevenagel-Thia-Michael Reaction: An Efficient and Multicomponent Strategy for Synthesis of 1,3-Thiazines
| Autor: | Anjali Srivastava, Arjita Srivastava, Malik A. Waseem, Shayna Shamim, Rahila, Shireen, Ibadur R. Siddiqui, Pragati Rai |
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| Rok vydání: | 2015 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Organic Chemistry 010402 general chemistry 01 natural sciences Aldehyde Domino 0104 chemical sciences chemistry.chemical_compound chemistry Atom economy Yield (chemistry) Ionic liquid Michael reaction Organic chemistry Reactivity (chemistry) Knoevenagel condensation |
| Zdroj: | Journal of Heterocyclic Chemistry. 53:1284-1291 |
| ISSN: | 0022-152X |
| DOI: | 10.1002/jhet.2379 |
| Popis: | An efficient, three-component strategy for synthesis of 1,3-thiazines with high atom economy in one-pot mediated by room temperature basic ionic liquid is described here. The strategy involves basic ionic liquid, [bmim]OH-catalyzed Knoevenagel condensation between ethyl cyanoacetate and aromatic aldehyde and subsequent thia-Michael addition with substituted thioureas. The reaction sequence is smooth and quantitative under ambient temperature. [bmim]OH was recovered and reused four times without any appreciable decrease in its reactivity and product yield. |
| Databáze: | OpenAIRE |
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