| Autor: |
Theresa K. Leslie, William J. Brackenbury, Patten L, Frank Riemer, J. D. Kaggie, O'Duinn Jm, Wiggins L, Langer S, Gabrielle C Baxter, Mary A. McLean, Andrew D. James, Aneurin J. Kennerley, Labarthe M, Fiona J. Gilbert |
| Rok vydání: |
2021 |
| Předmět: |
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| DOI: |
10.1101/2021.04.14.439494 |
| Popis: |
Breast cancer is the leading cause of cancer-related death in women worldwide. Development of novel noninvasive diagnostic and predictive pathophysiological biomarkers would represent a significant clinical improvement. Here, we explored the utility of non-invasive 23Na MRI to profile tumour physiology using preclinical mouse models of breast cancer. We establish that tissue Na+ concentration ([Na+]) is elevated vs non-tumour regions across multiple different tumour models. Ex vivo SBFI fluorescence imaging corroborated that this elevation in tumour [Na+] is due to increased intracellular [Na+]. Effective treatment with cytotoxic chemotherapy reduced tumour tissue [Na+], but was not detected by 1H diffusion-weighted imaging (DWI). Moreover, combining 23Na MRI and DWI measurements enabled superior classification accuracy of tumour vs non-tumour regions compared to either parameter alone. Quantification of breast tumour tissue [Na+] using 23Na MRI thus represents a novel, accurate, non-invasive diagnostic and predictive imaging biomarker. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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