Spiroxins, DNA cleaving antitumor antibiotics from a marine-derived fungus
| Autor: | Darren Robert Abbanat, Guy T. Carter, Michael Greenstein, Korshalla Joseph D, Valerie S. Bernan, Carolyn M. Discafani, Mark Tischler, Katarzyna Janota, Piotr Lassota, Leonard A. McDonald, Laurel R. Barbieri |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
biology
medicine.drug_class Organic Chemistry Antibiotics Nuclear magnetic resonance spectroscopy Fungus biology.organism_classification Biochemistry Molecular biology chemistry.chemical_compound Mechanism of action chemistry Ovarian carcinoma Drug Discovery medicine medicine.symptom Cytotoxicity Antitumor Antibiotics DNA |
| Zdroj: | Tetrahedron Letters. 40:2489-2492 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/s0040-4039(99)00242-7 |
| Popis: | The spiroxins (1–5) were purified from the culture extract of a marine-derived fungus. Their unique bisnaphthospiroketal structures were established by NMR spectroscopy. In addition to cytotoxicity, these compounds showed antibiotic activity and were active in a mouse xenograft model against human ovarian carcinoma. The mechanism of action of these compounds was shown to be due, in part, to their effect on DNA. |
| Databáze: | OpenAIRE |
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