Evaluation and improvement of organic semiconductors’ biocompatibility towards fibroblasts and cardiomyocytes
| Autor: | Jan Víteček, Lenka Švihálková Šindlerová, Lukáš Kubala, Stanislav Stříteský, Martin Vala, Eva Šafaříková, Martin Weiter |
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| Rok vydání: | 2018 |
| Předmět: |
Biocompatibility
Biointerface 02 engineering and technology engineering.material 010402 general chemistry 01 natural sciences Pentacene chemistry.chemical_compound Coating PEDOT:PSS Materials Chemistry Electrical and Electronic Engineering Instrumentation chemistry.chemical_classification Chemistry Metals and Alloys Polymer 021001 nanoscience & nanotechnology Condensed Matter Physics 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Organic semiconductor Chemical engineering engineering Wetting 0210 nano-technology |
| Zdroj: | Sensors and Actuators B: Chemical. 260:418-425 |
| ISSN: | 0925-4005 |
| Popis: | The use of organic semiconductors in bioelectronic devices has received considerable attention over the past decade, since they have the potential to form an excellent biointerface for living cells and tissues. The aim was to determine multiple aspects of the biocompatibility of selected organic semiconductors with high conductivity and to further improve their potential for cell cultivation. Two representatives of low-molecular weight organic semiconductors triisopropylsilyethynyl pentacene (TIPS-Pentacene) and diketopyrrolopyrrole (DPP(TBFu)2) were selected together with two semiconducting organic polymers poly(3-hexylthiophene-2,5-diyl) (P3HT) and poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS). The stability of these materials in physiological environment and their wetting properties, which are preconditions for biocompatibility, were determined. TIPS-Pentacene, DPP(TBFu)2 and P3HT were stable but PEDOT:PPS produced some leachates. Native TIPS-Pentacene, DPP(TBFu)2 and P3HT exhibited lowered wettability. Their biocompatibility was studied by means of fibroblasts and differentiated cardiomyocytes. It was limited compared to standard cell culture plastics, thus coating of surface by proteins was applied. Among others collagen IV coating was shown to significantly improve biocompatibility of all tested organic semiconductors. Finally, cultures of spontaneously beating cardiomyocytes were established on TIPS-Pentacene, DPP(TBFu)2, P3HT and PEDOT:PSS. |
| Databáze: | OpenAIRE |
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