θ, a novel γ-aminobutyric acid type A receptor subunit
| Autor: | Paul J. Whiting, Dalip J. S. Sirinathsinghji, Keith A. Wafford, Robert P. Heavens, Smith David W, Louise Hewson, N. Brown, Michael Rigby, B. Le Bourdelles, Ruth M. McKernan, Timothy P. Bonnert, Sophie J. Farrar |
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| Rok vydání: | 1999 |
| Předmět: | |
| Zdroj: | Proceedings of the National Academy of Sciences. 96:9891-9896 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.96.17.9891 |
| Popis: | γ-Aminobutyric acid type A (GABA-A) receptors are a major mediator of inhibitory neurotransmission in the mammalian central nervous system, and the site of action of a number of clinically important drugs. These receptors exist as a family of subtypes with distinct temporal and spatial patterns of expression and distinct properties that presumably underlie a precise role for each subtype. The newest member of this gene family is the θ subunit. The deduced polypeptide sequence is 627 amino acids long and has highest sequence identity (50.5%) with the β1 subunit. Within the rat striatum, this subunit coassembles with α2, β1, and γ1, suggesting that γ-aminobutyric acid type A receptors consisting of arrangements other than αβ + γ, δ, or ɛ do exist. Expression of α2β1γ1θ in transfected mammalian cells leads to the formation of receptors with a 4-fold decrease in the affinity for γ-aminobutyric acid compared with α2β1γ1. This subunit has a unique distribution, with studies so far suggesting significant expression within monoaminergic neurons of both human and monkey brain. |
| Databáze: | OpenAIRE |
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