Ectopic Antenna Induction by Overexpression of CG17836/Xrp1 Encoding an AT-Hook DNA Binding Motif Protein in Drosophila

Autor:	Tatsurou Minami, Yoshiteru Oshima, Noriko Tsurui-Nishimura, Thanh Quang Nguyen, Hirofumi Furuhashi, Tomonori Katsuyama, Shoichiro Kurata
Rok vydání:	2013
Předmět:	Genetics Regulation of gene expression Decapentaplegic Cell growth Organic Chemistry General Medicine Compound eye Biology AT-hook Applied Microbiology and Biotechnology Biochemistry Analytical Chemistry Cell biology Imaginal disc Molecular Biology Hedgehog Gene Biotechnology
Zdroj:	Bioscience, Biotechnology, and Biochemistry. 77:339-344
ISSN:	1347-6947 0916-8451
Popis:	Drosophila imaginal discs are an excellent model system for studies of developmental plasticity. In imaginal discs, most cells adhere strictly to their specific identity, but some cells undergo transdetermination, a process wherein the determined identity switches to another disc-specific identity. In this study, we performed gain-of-function screening and identified a gene, CG17836/Xrp1, that induces ectopic antennae in the eye field upon overexpression at the early eye disc stage. An essential factor in the distalization process, Distalles, and its upstream regulators Wingless, Hedgehog, and Decapentaplegic, are ectopically induced by CG17836/Xrp1 overexpression in eye discs, and this provides molecular evidence of the formation of ectopic antennae. Further, forced expression of CG17836/Xrp1 induced severe cell-proliferation defects. These findings suggest that CG17836/Xrp1 is involved in the regulation of cell proliferation in eye discs and affects disc identity specification.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0b37c79496cdb4dda0339d747ce47c77 https://doi.org/10.1271/bbb.120756 Zobrazit plný text záznamu