Long-Term Stability of Self-Assembled Monolayers in Biological Media

Autor:	and Michael J. Cima, Thanh-Nga T. Tran, Nolan T. Flynn, Robert Langer
Rok vydání:	2003
Předmět:	Analytical chemistry Self-assembled monolayer Surfaces and Interfaces Condensed Matter Physics Contact angle chemistry.chemical_compound chemistry X-ray photoelectron spectroscopy Desorption Monolayer Electrochemistry Moiety General Materials Science Ethylene glycol Voltammetry Spectroscopy
Zdroj:	Langmuir. 19:10909-10915
ISSN:	1520-5827 0743-7463
DOI:	10.1021/la035331e
Popis:	Undecanethiol (C11H23SH) and tri(ethylene glycol)-terminated undecanethiol (HO(C2H4O)3C11H22SH) self-assembled monolayers (SAMs) on clean gold surfaces were prepared and characterized. The SAMs were then immersed into either phosphate-buffered saline or calf serum. The SAM samples were investigated using several analytical techniques at numerous points over the next 35 days. Contact angles and current densities in voltammetry changed dramatically for the PBS samples over the time period, particularly after 21 days. Results indicate substantial loss of the integrity of the SAM. Similar alterations with time were observed for the calf serum samples in both contact angle and voltammetry measurements. X-ray photoelectron spectroscopy indicates that the likely origin is desorption of the alkanethiol moiety as evidenced by appreciable loss of the S 2p signal after 35 days.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0ae6062edac909f6c66a7f022bbf4e00 https://doi.org/10.1021/la035331e Zobrazit plný text záznamu