Membrane characteristics and functional activity of phagocytic alveolar macrophages

Autor:	Ershov Fi, Pelevina, Grigorian Ss, Fedorovskaia Eo, Afanas'ev Gg
Rok vydání:	1989
Předmět:	Inoculation Chemistry Phagocytosis Vasodilation General Medicine medicine.disease General Biochemistry Genetics and Molecular Biology Metastasis Dipyridamole Interferon Immunology Carcinoma medicine Cancer research Inducer medicine.drug
Zdroj:	Bulletin of Experimental Biology and Medicine. 107:83-86
ISSN:	1573-8221 0007-4888
Popis:	The intravascular (iv) or intramuscular (im) inoculations of a suspension of Lewis carcinoma cells induced metastatic tumor nodules in the lungs of C57Bl/6 mice. The administration of curantil (dipyridamole) (500 mg per 20 g-mouse, per os) once a week beginning one day after iv tumor cells inoculation (2 X 10(5) cells) reduced 4-fold the number of tumor nodules. The administration of curantil one day after im tumor cells inoculation (2 X 10(6) cells) reduced 2-fold the number of tumor nodules. The combined treatment of curantil (4-, 10-days after inoculation) and well-known inducer of interferon poly I:poly C (50 mg per 20 g-mouse, 1-, 7-, 14-days after inoculation tumor cells) had no synergistic effect.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0a9db39a052c55c817f45fb04367baf2 https://doi.org/10.1007/bf00837067 Zobrazit plný text záznamu Full text from SpringerLink