The influence of immunoregulatory cytokines IL-2, IL-7, and IL-15 upon activation, proliferation, and apoptosis of immune memory T-cells in vitro

Autor: A. A. Gutsol, Larisa Litvinova, K. A. Kofanova, N. A. Sokhonevich
Rok vydání: 2013
Předmět:
Zdroj: Cell and Tissue Biology. 7:539-544
ISSN: 1990-5203
1990-519X
Popis: The influence of immunoregulatory cytokines IL-2, IL-7, and IL-15 on the activation, proliferation, and apoptosis of different subpopulations of an immune memory T-cell (CD45RO+) in healthy donors were investigated. It was demonstrated that rIL-2 equally affected both the activation and proliferation of CD4+ and CD8+ subpopulations of memory T-cells in vitro. High concentrations of rIL-2 increased the number of CD8+ memory cells expressing apoptotic marker CD95. Effect of rIL-7 and rIL-15 on the activation and proliferation of cytotoxic CD8+ memory cells in vitro was different. CD4+ memory lymphocytes exhibited relative resistance to activation and proliferation by rIL-7 and rIL-15 compared to rIL-2. This can provide them with relative resistance to apoptosis, as well as create the necessary conditions for accelerated implementation of their functional capacity in the development of a secondary immune response.
Databáze: OpenAIRE
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