Serumkonzentration von Glyceroltrinitrat (GTN) bei transdermaler Applikation von GTN-Pflastern unterschiedlicher Provenienz*

Autor:	G. Menke, N. Rietbrock, H. Letzel, R. Heidemann
Rok vydání:	2008
Předmět:	Chromatography Therapeutic equivalency Nitroderm TTS Chemistry Healthy subjects General Medicine Serum concentration Crossover study Transdermal
Zdroj:	DMW - Deutsche Medizinische Wochenschrift. 110:1568-1572
ISSN:	1439-4413 0012-0472
DOI:	10.1055/s-2008-1069048
Popis:	Serum levels of glyceryl trinitrate have been determined in eight healthy subjects following transdermal application of four different glyceryl trinitrate plasters using a randomised crossover design. The plasters investigated were Deponit 10, Nitradisc 10, Nitroderm TTS 10 and Nitro-Pflaster-ratiopharm 10. The medians of serum concentrations arranged in decreasing order were 0.17-0.23 ng/ml for Nitroderm TTS 10, 0.13-0.21 ng/ml for Nitradisc 10, 0.08-0.13 ng/ml for Deponit 10, and 0.04-0.09 ng/ml for Nitro-Pflaster-ratiopharm 10. Corresponding areas under the concentration-time curves (AUC 0-24) were 23.15 nmol . h/l (Nitroderm TTS), 20.32 nmol . h/l (Nitradisc), 10.39 nmol . h/l (Deponit), and 5.7 nmol . h/l (Nitro-Pflaster-ratiopharm).
Databáze:	OpenAIRE
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