Mechanistic investigations of the formation of TTF derivatives via the phosphonate way
| Autor: | H-J Cristau, E. Torreilles, J-M Fabre, F. Darviche |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
chemistry.chemical_classification
endocrine system Ttf derivatives Organic Chemistry Deamination Salt (chemistry) respiratory system Biochemistry Combinatorial chemistry Phosphonate Acetic acid concentration Adduct chemistry.chemical_compound chemistry Nucleophile Yield (chemistry) Drug Discovery Organic chemistry |
| Zdroj: | Tetrahedron Letters. 39:2103-2106 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/s0040-4039(98)00061-6 |
| Popis: | We studied the influence of acetic acid concentration on the deamination and dephosphonylation of the adduct resulting of the nucleophilic reaction between adequate α-metalated phosphonate and imminium salt. to enhance the yield of such reactions in order to access efficiently a lot of unsymmetrical TTF derivatives. A mechanism is proposed for the formation of TTF, including steps, i1 to i-. The potential concurrent formation of phosphonate 1 and other by-products is also discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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