CXCR2 inhibition protects against chronic pancreatitis in a murine model
| Autor: | Colin J. McKay, Owen J. Sansom, Jen Morton, Thomas J. Evans, C.R. Carter, Colin W. Steele |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Hepatology business.industry Endocrinology Diabetes and Metabolism Gastroenterology medicine.disease medicine.disease_cause Elevated diastolic blood pressure Endocrinology Insulin resistance Internal medicine Pancreatic cancer medicine Etiology Pancreatitis CXC chemokine receptors Metabolic syndrome business Carcinogenesis |
| Zdroj: | Pancreatology. 13:e5 |
| ISSN: | 1424-3903 |
| Popis: | s / Pancreatology 13 (2013) e1–e20 e5 Conclusion: Components of the metabolic syndrome, which are associated with insulin resistance, namely elevated diastolic blood pressure, elevated serum HbA1c and decreased serum HDL were positively associated with large increases in the risk of pancreatic cancer. Factors influencing these parameters should be measured in future aetiological work and may suggest mechanisms for carcinogenesis, but support an aetiological role for insulin resistance in pancreatic cancer. Take-home message: Metabolic factors and serum HDL may be predicitve of the risk of developing pancreatic cancer. Abstract previously presented? yes (BSG) Any disclosures? no () |
| Databáze: | OpenAIRE |
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