| Popis: |
Obesity is a costly public health epidemic which contributes to increased morbidity and mortality from cardiovascular disease (CVD) and diabetes mellitus (DM). Insulin resistance (IR), the crucial underlying link between obesity and CVD, is associated with adipose tissue dysfunction. IR drives unopposed upregulation of proinflammatory and prothrombic factors resulting in systemic inflammation, oxidative stress, and a prothrombic environment. Among the resultant effects are hypertension, atherogenic dyslipidemia, and impaired glycemic control, which are all risk factors for CVD. Inflammation and oxidative stress also underlie vascular endothelial dysfunction and a favorable milieu for the promotion of atherosclerosis. Through understanding the mechanisms by which IR links obesity to CVD, health professionals can educate their patients about ways to maintain weight loss and prevent weight gain and, thus, slow the obesity epidemic and reduce CVD morbidity and mortality. |
