Behavioral Testing in the Context of Reproductive and Developmental Toxicity Screening in the West

Autor:	W. P. Weisenburger, J. L. Schardein, R. G. York
Rok vydání:	1992
Předmět:	Embryology Screening test Pediatrics Perinatology and Child Health Behavioral testing Developmental toxicity Positive control Animal behavior Context (language use) General Medicine Pharmacology Biology Developmental Biology Clinical psychology
Zdroj:	Congenital Anomalies. 32:15-29
ISSN:	1741-4520 0914-3505
DOI:	10.1111/j.1741-4520.1992.tb00777.x
Popis:	Methods for assessing animal neurobehavior following prenatal/perinatal exposures have been in use for almost 20 years and screening tests incorporating them are regulated in three settings: in Japanese Segment II and III studies on drugs, European (EEC/UK) Segment I studies on drugs, and American neurotoxicity studies on chemicals. The methods used in the West for assessing behavior in these contexts at present are described in detail. The evolution of the methods over time, the concepts of apical tests and functional domains, the use of positive control agents, what the U.S. Collaborative Study has shown us, and justification for assessing animal behavior in predicting outcome from human exposures are discussed.
Databáze:	OpenAIRE
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