Regional assignment of the mouse αA2-crystallin gene (Crya-1) to chromosome 17A3→B by in situ hybridization

Autor:	Nancy Weber Kaye, R.L. Church, J.M. Petrash, Peter A. Lalley
Rok vydání:	1990
Předmět:	Genetics Structural gene Chromosome In situ hybridization Biology biology.organism_classification Molecular biology Chinese hamster Chromosome 17 (human) Gene mapping Crystallin Molecular Biology Genetics (clinical) Southern blot
Zdroj:	Cytogenetic and Genome Research. 53:95-96
ISSN:	1424-859X 1424-8581
DOI:	10.1159/000132903
Popis:	Previously, we assigned the αA2-crystallin (Crya-1) structural gene to mouse chromosome 17 via Southern blot hybridization analysis of mouse × Chinese hamster somatic cell hybrids. Using in situ hybridization, we have now localized this gene to 17A3→B, a subchromosomal region containing several genes whose linkage relationships have been shown to be conserved on human chromosome 6. In man, however, the homologous gene (CRYA1) is located on human chromosome 21, indicating that internal rearrangements can occur within highly conserved chromosomal regions during the divergence of man and mouse.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0873c5f26385811151054fae86b0504f https://doi.org/10.1159/000132903 Zobrazit plný text záznamu