Primary Lung Cribriform Adenocarcinoma With Squamoid Morules Harboring Somatic CTNNB1 Mutation in a Never-Smoked Healthy Adolescent
| Autor: | Tracey L. Weigel, Jeremy Rosenblum, Qiqi Ye, Minghao Zhong, Hao Wu, Dana Razzano, Oya Tugal |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Beta-catenin Somatic cell medicine.disease_cause Malignancy Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine medicine In patient Mutation Lung biology business.industry General Medicine medicine.disease 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health Cribriform biology.protein Adenocarcinoma business |
| Zdroj: | Pediatric and Developmental Pathology. 23:472-475 |
| ISSN: | 1615-5742 1093-5266 |
| DOI: | 10.1177/1093526620957219 |
| Popis: | Primary lung adenocarcinomas are rare in pediatric patients, and even rarer in patients without precedent malignancy or congenital malformation. Here we present the first reported case of primary lung cribriform adenocarcinoma with squamoid morules in a previously healthy adolescent female. Molecular testing identified CTNNB1 mutation in the tumor and excluded other common mutations in lung adenocarcinoma. Our case suggests molecular alterations to the same signaling pathway can lead to similar histomorphology regardless of the tissue of origin. |
| Databáze: | OpenAIRE |
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