Detection of IgG antibodies to desmoglein 3 and desmocollins 2 and 3 in mucosal dominant-type pemphigus vulgaris with severe pharyngalgia and hyperemia of the bulbar conjunctiva
| Autor: | Megumi Mizawa, Teruhiko Makino, Tadamichi Shimizu, Hiroshi Hara, Masao Hayashi, Yuri Seki, Takashi Hashimoto, Norito Ishii |
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| Rok vydání: | 2015 |
| Předmět: |
education.field_of_study
Pathology medicine.medical_specialty integumentary system business.industry Pemphigus vulgaris Dermatology Desmocollins medicine.disease Desmoglein Pemphigus Paraneoplastic pemphigus immune system diseases Immunology Desmoglein 3 medicine IgA pemphigus Desmosomal Cadherins skin and connective tissue diseases education business |
| Zdroj: | European Journal of Dermatology. 25:619-620 |
| ISSN: | 1952-4013 1167-1122 |
| Popis: | Pemphigus vulgaris (PV) is an autoimmune blistering skin disease where desmogleins (Dsgs), desmosomal cadherin-type cell adhesion molecules, are major autoantigens [1]. Desmocollins (Dscs) are another group of desmosomal cadherins [2]. Dsc1 was previously reported to be an autoantigen in subcorneal pustular dermatosis-type IgA pemphigus [3]. In addition, anti-Dsc antibodies also exist in patients with paraneoplastic pemphigus (PNP) or atypical pemphigus [4, 5]. We report here a patient with mucosal [...] |
| Databáze: | OpenAIRE |
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