THE ASSAY OF ORALLY ADMINISTERED ANDROGENS USING THE CHICK'S COMB

Autor:	Ralph I. Dorfman, Adeline S. Dorfman
Rok vydání:	1963
Předmět:	medicine.medical_specialty Endocrinology business.industry Endocrinology Diabetes and Metabolism Internal medicine Medicine General Medicine business
Zdroj:	Acta Endocrinologica. 42:240-244
ISSN:	1479-683X 0804-4643
DOI:	10.1530/acta.0.0420240
Popis:	A method for the assay of androgens is described whereby the test material mixed with the food is fed for 7 days starting with day-old chicks and the comb weight used as the end-point. When testosterone was assayed against itself, the mean potency ratio for 24 trials, using from 36 to 80 chicks per trial, was 105% (range 69% to 141%). Statistically significant differences could not be found for the slopes, and λ varied from 0.13 to 0.40 (mean = 0.248). The following relative potencies (testosterone = 100) were found: 19-nortestosterone 76, androst-4-ene-3,17-dione 71, methyltestosterone 63, 11α-hydroxy-androst-4-ene-3,17-dione 57, 11β-hydroxy-androst-4-ene-3,17-dione 39, adrenosterone 32, androstane-3,17-dione 24, 17β-hydroxyandrostan-3-one 14, dehydroepiandrosterone 7, epiandrosterone 6, 17α-methyl-androst-5-ene3β,17β-diol 5.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::073631ace253eece2d945341eaf63054 https://doi.org/10.1530/acta.0.0420240 Zobrazit plný text záznamu