Glioneuronal tumors: clinicopathological findings and treatment options

Autor:	Lidia Gatto, Enrico Franceschi, Vincenzo Di Nunno, Alba A. Brandes, Stefania Bartolini, Chiara Tomasello
Rok vydání:	2020
Předmět:	Oncology 03 medical and health sciences medicine.medical_specialty 0302 clinical medicine Neurology business.industry 030220 oncology & carcinogenesis Internal medicine Medicine Treatment options Neurology (clinical) business 030217 neurology & neurosurgery
Zdroj:	Future Neurology. 15
ISSN:	1748-6971 1479-6708
DOI:	10.2217/fnl-2020-0003
Popis:	Glioneuronal tumors are very rare CNS neoplasms that demonstrate neuronal differentiation, composed of mixed glial and neuronal cells. The majority of these lesions are low grade and their correct classification is crucial in order to avoid misidentification as ‘ordinary’ gliomas and prevent inappropriate aggressive treatment; nevertheless, precise diagnosis is a challenge due to phenotypic overlap across different histologic subtype. Surgery is the standard of therapeutic approach; literature concerning the benefit of adjuvant treatments is inconclusive and a globally accepted treatment of recurrence does not exist. Targetable mutations in the genes BRAF and FGFR1/2 are recurrently found in these tumors and could take a promising role in future treatment management.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::07200a3f0b99def51a7fa2019cf391aa https://doi.org/10.2217/fnl-2020-0003 Zobrazit plný text záznamu