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In an attempt to improve the physicochemical properties of poorly aqueous soluble ezetimibe, its pharmaceutical co-crystals were successfully engineered with different crystal forming agents; benzoic acid and salicylic acid in equimolar ratios by solution crystallization technique. The physicochemical properties of pure ezetimibe and corresponding co-crystals were accessed in terms of phase solubility studies, melting point, flowability, drug content uniformity, saturation solubility and dissolution studies. Fourier transformation infrared spectroscopy (FTIR), X-ray powder diffractometry (XRPD) and scanning electron microscopy (SEM) techniques were employed to investigate the hydrogen bonding interaction, crystallinity and surface morphological characteristics of prepared co-crystals respectively. The results indicated a marked improvement in flow properties and saturation solubility of co-crystals (p |
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