Dextran deposition in reticuloendothelial organs in hemodialysis patients: A forgotten adverse effect of low‐molecular weight dextran
| Autor: | Yoshihiro Ikura, Yasuhiro Iwai, Hidetoshi Okabe, Toru Yokokawa |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty business.industry medicine.medical_treatment 030232 urology & nephrology Autopsy Hematology Mononuclear phagocyte system 030204 cardiovascular system & hematology medicine.disease 03 medical and health sciences chemistry.chemical_compound Low molecular weight dextran 0302 clinical medicine Dextran chemistry Nephrology Ascites medicine Hydrothorax Hemodialysis medicine.symptom business Adverse effect |
| Zdroj: | Hemodialysis International. 24 |
| ISSN: | 1542-4758 1492-7535 |
| DOI: | 10.1111/hdi.12848 |
| Popis: | We present two autopsy cases of refractory ascites/hydrothorax associated with systemic deposition of low-molecular weight dextran that had been used in hemodialysis over an extended period. The most striking autopsy findings in both cases were dense accumulation of dextran-laden macrophages in sinusoids of reticuloendothelial organs. These accumulated macrophages seemed to have disturbed blood and lymph flow. Based on these findings, we concluded that the persistent ascites and hydrothorax were attributable to systemic deposition of dextran, especially the accumulation of dextran-laden macrophages in the reticuloendothelial organs. We suggest that dextran solution should immediately be designated as contraindicated for hemodialysis patients. |
| Databáze: | OpenAIRE |
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