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Background: The gender-related differences in clinical course of Behcet’s disease (BD) are well-established, and more severe course is usually observed among young males. Objectives: To analyze the effect of gender on the severity and clinical features of BD. Methods: The study included 425 patients (male – 285, female – 140) with BD (according to ISGBD 1990 and ICBD criteria 2014) [1, 2]. The male-to-female ratio was 2:1, the mean age was 33,2±10,2 yrs, the median of disease duration - 134,3 [60,0; 192,0] months. Results: BD severity depending on gender We observed the following gender-related differences in clinical manifestations of BD: males significantly more often had uveitis (74% vs 57%, p=0,0003), optic neuritis (11% vs 0%, p=0,0004), blindness (9% vs 2,5%, p=0,04); cutaneous lesions (89% vs 71%, p Conclusion: An association of severe clinical manifestations (ophthalmological and vascular, such as large vessels and cerebral sinus thromboses), higher disease activity & severity, as well Disclosure of Interests: None declared |
