Stimuli-responsive antifouling polyisobutylene-based biomaterials via modular surface functionalization

Autor: Judit E. Puskas, Emily Q. Rosenthal-Kim, Zhorro Nikolov, Lingyun Liu, Jozsef Kantor, Alejandra Alvarez Albarran
Rok vydání: 2017
Předmět:
Zdroj: Journal of Polymer Science Part A: Polymer Chemistry. 55:1742-1749
ISSN: 0887-624X
DOI: 10.1002/pola.28540
Popis: This article demonstrates a new, modular approach to surface functionalization that harnesses chain entanglement. A layer of functionalized polyisobutylene, (PIB)-ω, where ω = -OH, -thymine (T), -hexaethylene glycol (HEG), poly(ethylene glycol) (-PEG-OH), methoxy-functionalized poly(ethylene glycol) (-PEG-OCH3), and -tetraethylene glycol-α-lipoate (TEG-αL) was adhered to PIB-based thermoplastic elastomer (TPE) surfaces. X-ray photoelectron spectroscopy (XPS) at angles ranging from 20° to 75° showed decreasing polar group concentration with increasing penetration depth, confirming segregation of polar groups toward the surface. Water contact angle (WCA) of the PIB-based TPE dropped from 95° to 79°−83° upon coating, and soaking in water for 24 h further decreased the WCA. Dynamic WCA measurements showed 40–30° receding angles, showing that stimulus from an aqueous environment elicits enrichment of polar groups on the surface. Fibrinogen (Fg) adsorption on the various surfaces was quantified using surface plasmon resonance (SPR). Static and dynamic WCA did not vary significantly among TPE + PIB-ω surfaces, but there were dramatic differences in Fg adsorption: 256 ng/cm2 was measured on the native TPE, which dropped to 40 and 22 ng/cm2 on PIB-PEG-OCH3 and PIB-PEG-OH-coated surfaces. PIB-TEG-αL-coated surfaces presented the lowest Fg adsorption with 14 ng/cm2. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 1742–1749
Databáze: OpenAIRE
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