Polymorphism and gene organization of water buffalo MHC-DQB genes show homology to the BoLA DQB region
| Autor: | Loren C. Skow, Maria Paula Cruz Schneider, Rodney L. Honeycutt, James E. Womack, D. A. Honeycutt, Bertram Brenig, L. Sena |
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| Rok vydání: | 2011 |
| Předmět: |
Genetics
0303 health sciences Phylogenetic tree Nucleic acid sequence General Medicine Biology biology.organism_classification Major histocompatibility complex Homology (biology) 03 medical and health sciences 0302 clinical medicine biology.protein Gene family Animal Science and Zoology Bubalus Allele Gene 030304 developmental biology 030215 immunology |
| Zdroj: | Animal Genetics. 42:378-385 |
| ISSN: | 0268-9146 |
| DOI: | 10.1111/j.1365-2052.2010.02157.x |
| Popis: | In cattle (Bos taurus), there is evidence of more than 50 alleles of BoLA-DQB (bovine lymphocyte antigen DQB) that are distributed across at least five DQB loci, making this region one of the most complex in the BoLA gene family. In this study, DQB alleles were analysed for the water buffalo (Bubalus bubalis), another economically important bovine species. Twelve alleles for Bubu-DQB (Bubalis bubalis DQB) were determined by nucleotide sequence analysis. A phylogenetic analysis revealed numerous trans-species polymorphisms, with alleles from water buffalo assigned to at least three different loci (BoLA-DQB1, BoLA-DQB3 and BoLA-DQB4) that are also found in cattle. These presumptive loci were analysed for patterns of synonymous (d(S)) and non-synonymous (d(N)) substitution. Like BoLA-DQB1, Bubu-DQB1 was observed to be under strong positive selection for polymorphism. We conclude that water buffalo and cattle share the current arrangement of their DQB region because of their common ancestry. |
| Databáze: | OpenAIRE |
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