The butyrylcholinesterase K variant is a protective factor for sporadic Alzheimer's disease in women
| Autor: | M. Sanchez-Guerra, José Berciano, C. Fernandez-Viadero, Javier Llorca, Onofre Combarros, N. Pena, A. Alvarez-Arcaya |
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| Rok vydání: | 2000 |
| Předmět: |
Apolipoprotein E
medicine.medical_specialty General Medicine Odds ratio Biology medicine.disease Endocrinology Neurology Internal medicine Genotype medicine biology.protein lipids (amino acids peptides and proteins) Neurology (clinical) Allele Risk factor Alzheimer's disease Butyrylcholinesterase Cholinesterase |
| Zdroj: | Acta Neurologica Scandinavica. 102:350-353 |
| ISSN: | 0001-6314 |
| DOI: | 10.1034/j.1600-0404.2000.102006350.x |
| Popis: | INTRODUCTION Recent reports indicate that the K variant of the butyrylcholinesterase (BCHE) gene may act in synergism with the epsilon4 allele of apolipoprotein E (APOE) to increase the risk of Alzheimer's disease (AD), but this is controversial. MATERIAL AND METHODS We genotyped for the BCHE-K and APOE epsilon4 alleles in a sample of 249 AD patients and 250 controls derived from the same region in a Spanish population. RESULTS A protective effect of the K variant of BCHE with an odds ratio of 0.41 (95% confidence interval 0.19-0.86, P=0.02) was observed among non-APOE epsilon4 carriers, but it was limited to women. CONCLUSION Our study is the first to demonstrate that lower susceptibility to AD determined by the K variant of BCHE is dependent on gender. |
| Databáze: | OpenAIRE |
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