Cytotoxic Activity of Cu/TiO2 Nanoparticles on Uterine-Cervical Cancer Cells
| Autor: | Aida Hamdan-Partida, Miguel Angel Zavala Sánchez, Julia Pérez Ramos, Jaime Bustos-Martínez, Samuel González-García, Emma Elisa Ortiz Islas, Ruben Del Muro Delgado |
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| Rok vydání: | 2020 |
| Předmět: |
Thermogravimetric analysis
Materials science biology Scanning electron microscope Kinetics Biomedical Engineering chemistry.chemical_element Nanoparticle Bioengineering 02 engineering and technology General Chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics biology.organism_classification Copper HeLa Differential scanning calorimetry chemistry General Materials Science Fourier transform infrared spectroscopy 0210 nano-technology Nuclear chemistry |
| Zdroj: | Journal of Nanoscience and Nanotechnology. 20:7289-7298 |
| ISSN: | 1533-4880 |
| DOI: | 10.1166/jnn.2020.18740 |
| Popis: | Nanoparticles based on metal oxides serve as carrier matrices for molecules of biological interest. In this work, we used different copper complexes that were coupled to TiO2 nanoparticles. Nanoparticles were prepared with the sol–gel method. The Cu/TiO2 nanoparticles were characterized through ultraviolet-visible and Fourier transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis, nitrogen physisorption analysis, and scanning electron microscopy. Their biological activity was determined through DNA degradation and their cytotoxic effect on HeLa cells. The Cu/TiO2 nanoparticles presented a pore size between 2 and 6 nm, the size of nanoparticles agglomerates was between 100 and 500 nm. The nanoparticles of Cu/TiO2 degraded DNA starting at 15 min. The half maximal inhibitory concentration in HeLa cells depends on the used cooper complexes, the kinetics of cell death is of first order. Results revealed that these nanoparticles could be applied in uterine-cervical cancer treatment. |
| Databáze: | OpenAIRE |
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