| Autor: |
Srikantan S. Nagarajan, Valentina Borghesani, Sladjana Lukic, Maria Luisa Gorno-Tempini, Michael Lauricella, Susanne M. Honma, Leighton B. Hinkley, Bruce L. Miller, Danielle Mizuiri, John F. Houde, Corby L. Dale, Zachary A. Miller, Wendy Shwe |
| Rok vydání: |
2020 |
| Předmět: |
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| DOI: |
10.1101/2020.10.07.329698 |
| Popis: |
Semantic representations are processed along a posterior-to-anterior gradient reflecting a shift from perceptual (e.g., it has eight legs) to conceptual (e.g., venomous spiders are rare) information. One critical region is the anterior temporal lobe (ATL): patients with semantic variant primary progressive aphasia (svPPA), a clinical syndrome associated with ATL neurodegeneration, manifest a deep loss of semantic knowledge. We test the hypothesis that svPPA patients perform semantic tasks by over-recruiting areas implicated in perceptual processing. We compared MEG recordings of svPPA patients and healthy controls during a categorization task. While behavioral performance did not differ, svPPA patients showed indications of greater activation over bilateral occipital cortices and superior temporal gyrus, and inconsistent engagement of frontal regions. These findings suggest a pervasive reorganization of brain networks in response to ATL neurodegeneration: the loss of this critical hub leads to a dysregulated (semantic) control system, and defective semantic representations are seemingly compensated via enhanced perceptual processing.Impact StatementFollowing anterior temporal lobe neurodegeneration, defective semantic representations are compensated via enhanced perceptual processing and associated with a dysregulation of the semantic control system. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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