Copper-Catalyzed Cascade Annulation of Malonate-Tethered O-Acyl Oximes with Cyclic 1,3-Dicarbonyl Compounds for the Synthesis of Spiro-Pentacyclic Derivatives

Autor:	Kun Wang, Hong-Rong Guan, Hai-Tao Yang, Wen-Long Ren, Chun-Bao Miao
Rok vydání:	2021
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Annulation Malonate chemistry Cascade Organic Chemistry Copper catalyzed Regioselectivity Stereoselectivity Medicinal chemistry Tricyclic
Zdroj:	The Journal of Organic Chemistry. 86:12309-12317
ISSN:	1520-6904 0022-3263
DOI:	10.1021/acs.joc.1c01122
Popis:	A copper-catalyzed cascade annulation of malonate-tethered O-acyl oximes with cyclic 1,3-dicarbonyl compounds has been developed for the rapid synthesis of spiro-pentacyclic derivatives. This reaction allows the one-step formation of five C-C/N/O bonds and an angular tricyclic core under very mild conditions and shows excellent regioselectivity and stereoselectivity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::040ed11a67478efe0b51cc7e4cdbaacf https://doi.org/10.1021/acs.joc.1c01122 Zobrazit plný text záznamu