Developing a general strategy for the solid supported synthesis of heterocycles: Applications to the generation of molecular diversity and drug discovery

Autor:	J. P. Chinn, Hilary Dorr, Dane Goff, L. Wang, Paul A. Renhowe, Rajinder Singh, John M. Nuss, Ronald N. Zuckermann, Sharadha Subramanian, Edward G. Brown, Manoj C. Desai
Rok vydání:	1997
Předmět:	Peptidomimetic Chemistry Drug discovery General Chemical Engineering General Chemistry Computational biology respiratory system human activities Combinatorial chemistry Small molecule Diversity (business)
Zdroj:	Pure and Applied Chemistry. 69:447-452
ISSN:	1365-3075 0033-4545
DOI:	10.1351/pac199769030447
Popis:	The development of a general strategy for the generation of molecular diversity in the form of novel, non-amide based heterocyclic structures is described. The generation of diverse peptide and peptidomimetic libraries, the automation of these strategies and computational approaches to diversity generation are also discussed. The main focus of this lecture is the the progression of these concepts into a strategy for small molecule library generation, and hence the generation of small molecule therapeutic leads.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0363df3b70de5cf722db06c329a6a548 https://doi.org/10.1351/pac199769030447 Zobrazit plný text záznamu