One-step microwave-assisted synthesis of water-dispersible Fe 3 O 4 magnetic nanoclusters for hyperthermia applications
| Autor: | Ayyappan Sathya, John Philip, Surojit Ranoo, S. Kalyani |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Materials science
Iron oxide Nanoparticle Nanotechnology 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences 0104 chemical sciences Electronic Optical and Magnetic Materials Nanoclusters Colloid chemistry.chemical_compound Magnetic hyperthermia chemistry Chemical engineering Magnetic nanoparticles 0210 nano-technology Ethylene glycol Microwave |
| Zdroj: | Journal of Magnetism and Magnetic Materials. 439:107-113 |
| ISSN: | 0304-8853 |
| Popis: | To realize magnetic hyperthermia as an alternate stand-alone therapeutic procedure for cancer treatment, magnetic nanoparticles with optimal performance, within the biologically safe limits, are to be produced using simple, reproducible and scalable techniques. Herein, we present a simple, one-step approach for synthesis of water-dispersible magnetic nanoclusters (MNCs) of superparamagnetic iron oxide by reducing of Fe 2 (SO 4 ) 3 in sodium acetate (alkali), poly ethylene glycol (capping ligand), and ethylene glycol (solvent and reductant) in a microwave reactor. The average size and saturation magnetization of the MNC’s are tuned from 27 to 52 nm and 32 to 58 emu/g by increasing the reaction time from 10 to 600 s. Transmission electron microscopy images reveal that each MNC composed of large number of primary Fe 3 O 4 nanoparticles. The synthesised MNCs show excellent colloidal stability in aqueous phase due to the adsorbed PEG layer. The highest SAR value of 215 ± 10 W/g Fe observed in 52 nm size MNC at a frequency of 126 kHz and field of 63 kA/m suggest the potential use of these MNC in hyperthermia applications. This study further opens up the possibilities to develop metal ion-doped MNCs with tunable sizes suitable for various biomedical applications using microwave assisted synthesis. |
| Databáze: | OpenAIRE |
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