Diabetic microangiopathy in KK mice
| Autor: | Rafael A. Camerini-Davalos, Werner Oppermann, A.S. Reddi, Theodore Ehrenreich, D. G. Patel |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Diabetic microangiopathy
medicine.medical_specialty medicine.drug_class business.industry medicine.medical_treatment Insulin Clinical Biochemistry Glomerulosclerosis Glomerulonephritis medicine.disease Sulfonylurea Pathology and Forensic Medicine Endocrinology Diabetes mellitus Internal medicine medicine Diabetic glomerulosclerosis business Molecular Biology Saline |
| Zdroj: | Experimental and Molecular Pathology. 29:92-101 |
| ISSN: | 0014-4800 |
| DOI: | 10.1016/0014-4800(78)90029-1 |
| Popis: | KK mice with spontaneous hereditary diabetes and human diabetic-like glomerulosclerosis were treated with either 0.5 or 2.5 mg/kg of glyburide, a sulfonylurea compound, from 2 months of age. Both, saline and glyburide-treated mice were sacrificed at 4, 6, 9, and 12 months of age, and their kidneys were examined by light microscopy. The data indicate that early glyburide treatment is effective in ameliorating or delaying the progression of diabetic glomerulosclerosis. This effect seems to be related to the early control of hyperglycemia in KK mice. |
| Databáze: | OpenAIRE |
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