Synthesis of a new series of purine derivatives and their anti-cyclin-dependent kinase activities

Autor:	Laurent Meijer, Michel Legraverend, Odile Ludwig, Sophie Leclerc
Rok vydání:	2001
Předmět:	chemistry.chemical_compound chemistry biology Kinase Cyclin-dependent kinase Stereochemistry Organic Chemistry Substituent biology.protein Purine derivative Cell cycle
Zdroj:	Journal of Heterocyclic Chemistry. 38:299-303
ISSN:	0022-152X
DOI:	10.1002/jhet.5570380145
Popis:	The synthesis of new purine derivatives designed to inhibit cell cycle regulating cyclin-dependent kinases (CDKs), is reported. These compounds, related to olomoucine and roscovitine, are characterised by the presence of apyrrolidine methanol substituent at C-2 and a variety of ortho, meta and/or para substituents on the C-6 arylamino group.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::029645ba47ab636aadcd6cdcdc4fcd25 https://doi.org/10.1002/jhet.5570380145 Zobrazit plný text záznamu Plný text