Boron Neutron Capture Therapy of a Murine Mammary Carcinoma using a Lipophilic Carboranyltetraphenylporphyrin1
| Autor: | Peggy L. Micca, Ruimei Ma, G. M. Morris, Diana T. Lombardo, Kelly M. Youngs, Daniel N. Slatkin, Duane A. Hoch, Michiko Miura, Jeffrey A. Coderre, John Kalef-Ezra |
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| Rok vydání: | 2001 |
| Předmět: |
inorganic chemicals
Pathology medicine.medical_specialty Radiation Chemistry Ratón Radiochemistry Mammary gland Biophysics chemistry.chemical_element Phenylalanine medicine.disease Neutron capture medicine.anatomical_structure In vivo Carcinoma medicine Radiology Nuclear Medicine and imaging Drug carrier Boron |
| Zdroj: | Radiation Research. 155:603-610 |
| ISSN: | 1938-5404 0033-7587 |
| DOI: | 10.1667/0033-7587(2001)155[0603:bnctoa]2.0.co;2 |
| Popis: | Miura, M., Morris, G. M., Micca, P. L., Lombardo, D. T., Youngs, K. M., Kalef-Ezra, J. A., Hoch, D. A., Slatkin, D. N., Ma, R. and Coderre, J. A. Boron Neutron Capture Therapy of a Murine Tumor using a Lipophilic Carboranyltetraphenylporphyrin. The first control of a malignant tumor in vivo by porphyrin- mediated boron neutron capture therapy (BNCT) is described. In mice bearing implanted EMT-6 mammary carcinomas, boron uptake using a single injection of either p-boronophenylalanine (BPA) or mercaptoundecahydrododecaborane (BSH) was compared with either a single injection or multiple injections of the carboranylporphyrin CuTCPH. The BSH and BPA doses used were comparable to the highest doses of these compounds previously administered in a single injection to rodents. For BNCT, boron concentrations averaged 85 μg 10B/g in the tumor and 4 μg 10B/g in blood 2 days after the last of six injections (over 32 h) that delivered a total of 190 μg CuTCPH/g body weight. During a single 15, 20, 25 or 30 MW-m... |
| Databáze: | OpenAIRE |
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