Stężenie białka S100B w surowicy krwi dawców narządów po stwierdzonej śmierci mózgu — doniesienie wstępne
| Autor: | Piotr Knapik, Wojciech Saucha, Piotr F. Czempik, Danuta Kokocińska, Łukasz J. Krzych |
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| Rok vydání: | 2015 |
| Předmět: |
Brain dead
medicine.medical_specialty Pathology business.industry Case-control study General Medicine Brain damage Critical Care and Intensive Care Medicine Gastroenterology Anesthesiology and Pain Medicine Internal medicine Predictive value of tests Reflex Medicine Organ donation medicine.symptom business S100b protein S100 Calcium Binding Protein beta Subunit |
| Zdroj: | Anestezjologia Intensywna Terapia. 47:320-323 |
| ISSN: | 1731-2515 1642-5758 |
| Popis: | BACKGROUND: Protein S100B is considered to be a marker of brain damage, but there is a paucity of data regarding the utility of its assessment in brain-dead organ donors. The aim of the study was to compare serum protein S100B concentrations between brain-dead organ donors and patients with a confirmed permanent neurological deficit but without signs of brain death. METHODS: The concentration of serum S100B protein was measured in 12 brain-dead organ donors (including 7 males with a median age of 40 years). All measurements were taken when brain death was confirmed by the commission. Twenty-nine patients (including 13 males with a median age of 63 years) who died in the medical ICU with confirmed permanent brain injury without signs of brain death acted as controls. In these patients, S-100B protein measurements were performed upon ICU admission. RESULTS: In brain-dead organ donors, the median values of serum S100B protein were much higher in comparison to the control group (median and IQR, respectively: 5.04 μg L -1 ; 1.775−6.765 vs 0.897 μg L -1 ; 0.324−1.880, P 1.81 μg L -1 predicted brain death with the highest accuracy (AUROC = 0.83; 95% CI 0.68−0.93; P < 0.001). CONCLUSION: Concentrations of serum S100B protein in brain-dead organ donors are extremely high and may support the diagnosis of brain death. This fact may be of value when the presence of reflex movements (frequently reported despite brain death) might delay determination of brain death and result in the failure of organ donation. |
| Databáze: | OpenAIRE |
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