| Autor: |
Kezeli Td, N.M. Dolidze, Gongadze Nv, M.V. Okujava, Golovach Sv, M. Chipashvili, Sukoyan Gv |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Cardiovascular Pharmacology: Open Access. |
| ISSN: |
2329-6607 |
| DOI: |
10.4172/2329-6607.1000225 |
| Popis: |
Backgrounds: Short-term sustained beta-adrenergic stimulation is a hallmark of sympathetic hyperactivity and a common future in cardiovascular disease. Activation of endogenous cell signaling pathways that negatively regulate cardiac hypertrophy including the decline of NAD and the reduction of the intracellular NAD+/NADH ratio. The hypothesis that prevention of NAD depletion in myocardium may be critical in the treatment of cardiac hypertrophy and inflammatory responses was tested. Methods: On the 7 days of isoproterenol (ISO)-induced cardiac hypertrophy (CH) all animals were randomly assigned into 3 groups: control-without therapy (infusion of 0,9% NaCl); main I-receive 10 mg/kg nebivolol per os in combination with lisinopril infusion; and main II-receive infusion of 15 mg/kg of Nadcin® dissolved in water for injection. All animals were euthanized throughout 7 days after beginning of treatment. Results and conclusion: The increases of heart weight by 18,6% and heart-to-body weight ratio by 35,5% observed in ISO-induced CH were significantly suppressed in lisinopril-nebivolol therapy and monotherapy with NAD+- containing drug, Nadcin®. Therapy with Nadcin® restored the normal level of NAD+/NADH ratio and norepinephrine, in myocardium and cerebral arteries, decrease level of nuclear factor kappa B (NF-kB) and tumor necrosis factor (TNF)- alpha in myocardium, cerebral arteries and blood and as a result blocking the myocardial hypertrophy progression. Treatment with Nadcin® on the ISO-induced model of cardiac injury in rabbits occurs significant anti-hypertrophic and anti-inflammatory effects and occurs preventive action on the redox-potential, NAD+/NADH decreasing and NAD+ depletion of myocardium and redox-potential decreasing in cerebral arteries. Thus, therapeutic strategy for NAD repletion have shown high therapeutic potential for cardiac, vascular and neurologic diseases. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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