Growth monitoring and mortality risk in low birthweight infants: a birth cohort study in Burkina Faso
| Autor: | Moses Ngari, Marie McGrath, Paluku Bahwere, Martha Mwangome, James A. Berkley, Patrick Kabore |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pediatrics medicine.medical_specialty 030109 nutrition & dietetics Proportional hazards model business.industry Health Policy Birth weight Hazard ratio Public Health Environmental and Occupational Health Medicine (miscellaneous) Anthropometry Biochemistry Genetics and Molecular Biology (miscellaneous) 03 medical and health sciences Low birth weight 0302 clinical medicine Immunology and Microbiology (miscellaneous) medicine 030212 general & internal medicine medicine.symptom Underweight business Wasting Weight gain |
| Zdroj: | Gates Open Research. 5:82 |
| ISSN: | 2572-4754 |
| DOI: | 10.12688/gatesopenres.13231.1 |
| Popis: | Background: Wasting and underweight in infancy is an increasingly recognised problem but consensus on optimum assessment is lacking. In particular, there is uncertainty on how to interpret anthropometry among low birth weight (LBW) infants who may be growing normally. This research aimed to determine growth of infants from birth to two months (around age of vaccination) and the mortality risk of underweight LBW infants compared to normal birth weight (NBW) infants at two and six months age. Methods: A secondary analysis of a birth cohort of 1103 infants in Burkina Faso was conducted. Anthropometry was performed monthly from 0 to 12 months. We assessed associations with mortality using Cox proportional hazards models and assessed discriminatory values using area under receiver operating characteristics curves. Results: Eighty-six (7.8%) children died by age one year, 26/86 (30%) and 51/86 (59%) within two and six months, respectively. At age two months, weight gain since birth did not better discriminate mortality risk than current weight-for-age (P=0.72) or mid-upper arm circumference (P=0.21). In total, 227 (21%) LBW infants had increased risk of mortality: adjusted hazards ratio (aHR) 3.30 (95%CI 2.09 to 4.90). Among infants who were underweight at two and six months, LBW infants (64% and 49%, respectively) were not at reduced risk of death compared to NBW infants (aHR 2.63 (95%CI 0.76 to 9.15) and 2.43 (95%CI 0.74 to 7.98), respectively). Conclusion: Assessing weight gain since birth does not offer advantages over immediate anthropometry for discriminating mortality risk. LBW infants who are later identified as underweight require care to help prevent mortality. |
| Databáze: | OpenAIRE |
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