IMPORTANCE OF ANTIBODIES TO 21-HYDROXYLASE FOR THE DIAGNOSIS, DIFFERENTIAL DIAGNOSIS AND PROGNOSIS OF AUTOIMMUNE CHRONIC PRIMARY ADRENAL INSUFFICIENCY

Autor:	N.V. Makazan, V. A. Peterkova, L.V. Nikankina, E. M. Orlova, L. S. Sozaeva, N.M. Malysheva, M. A. Kareva
Rok vydání:	2021
Předmět:	Pathology medicine.medical_specialty Chronic Primary Adrenal Insufficiency biology business.industry Pediatrics Perinatology and Child Health 21-Hydroxylase biology.protein Medicine Differential diagnosis Antibody business
Zdroj:	Pediatria. Journal named after G.N. Speransky. 100:78-86
ISSN:	1990-2182 0031-403X
DOI:	10.24110/0031-403x-2021-100-2-78-86
Popis:	21-hydroxylase (21-OH) is the main antigen of the adrenal cortex, so the determination of antibodies (Ab) to 21-OH can help in the diagnosis and prognosis of chronic primary adrenal insufficiency (CPAI). Purpose of the study: evaluation of the relevance of Ab to 21-OH for the diagnosis and prediction of autoimmune CPAI. Materials and methods of research: the study consisted of three blocks: 1) assessment of the specificity and sensitivity, as well as the prognostic potential of Ab to 21-OH in patients with polyglandular autoimmune syndrome (APS) – individuals with APS type 1 with and without CPAI (n=106); 2) assessment of the dynamics of the level of Ab to 21-OH – patients with autoimmune CPAI were included (n=41); 3) assessment of the significance of Ab data for the differential diagnosis of various forms of CPAI, including patients with CPAI and APS type 1 exclusion (n=30). The study of Ab to 21-hydroxylase was performed using enzymelinked immunosorbent assay (BioVendor kits, Czech Republic). Results: statistically significant differences were obtained in the frequency of detection of Ab to 21-OH in patients with or without PCNI (p
Databáze:	OpenAIRE
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