Stereoselective Synthesis of β-Amino-α-hydroxy(allyl)phosphinates and an Application to the Synthesis of a Building Block for Phosphinyl Peptides
| Autor: | Takehiro Yamagishi, Takanori Kusano, Shiroshi Shibuya, Tsutomu Yokomatsu |
|---|---|
| Rok vydání: | 2002 |
| Předmět: | |
| Zdroj: | Synlett. 2002:1471-1474 |
| ISSN: | 1437-2096 0936-5214 |
| Popis: | Hydrophosphinylation of N,N-dibenzyl-α-amino aldehydes with ethyl allylphosphinate in the presence of (S)-ALB afforded anti-β-amino-a-hydroxy(allyl)phosphinates in high diastereoselectivity. The hydrophosphinylation product was transformed to a potentially useful transition state mimic for hydrolysis of dipeptides. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|