Five-sixth Nephrectomy in Female Common Marmosets (Callithrix jacchus) as a Chronic Renal Failure Model
| Autor: | Kensuke Myojo, Itaru Yamaguchi, Chie Takada, Hiroko Sanada, Katsumi Takaba, Minami Imaizumi, Yui Suzuki, Koji Saeki, Atsuko Takami, Naoya Kimoto, Jyoji Yamate |
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| Rok vydání: | 2014 |
| Předmět: |
endocrine system
Creatinine medicine.medical_specialty biology Anemia business.industry medicine.medical_treatment Physiology Marmoset Toxicology medicine.disease biology.organism_classification Callithrix Nephrectomy Pathophysiology Pathology and Forensic Medicine chemistry.chemical_compound Endocrinology Hypocellularity chemistry Internal medicine biology.animal medicine Osteodystrophy business |
| Zdroj: | Journal of Toxicologic Pathology. 27:183-195 |
| ISSN: | 1881-915X 0914-9198 |
| DOI: | 10.1293/tox.2013-0055 |
| Popis: | To assess the relevance and availability of subtotal nephrectomized common marmoset monkeys as a chronic renal failure (CRF) model, we observed for 26 weeks the pathophysiological condition of female marmosets subjected to five-sixth surgical nephrectomy (5/6Nx) by a two-step surgical method. The 5/6Nx marmosets showed a significant increase in serum levels of urea nitrogen, creatinine and cystatin-C immediately after 5/6Nx surgery. These renal disorder parameters subsequently tended to decrease with the passage of time but remained higher than the control levels by the end of the study. Hyperplastic parathyroid glands, a high turnover state of osteodystrophy in the femoral bone with higher serum ALP activity and anemia with hypocellularity of bone marrow were evident. The 5/6Nx marmosets showed a stable CRF condition for a long time and some characteristic disorders similar to those observed in CRF patients. These diagnostic aspects might be a species-specific anatomical and physiological signature, reflecting the nutritional condition. The CRF model using 5/6Nx marmosets might become a useful method of evaluating the unique mechanism of CRF development. |
| Databáze: | OpenAIRE |
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