Corneal confocal microscopy identifies corneal nerve fiber loss in patients with migraine
| Autor: | Yigit Can Guldiken, Ioannis N Petropoulos, Ayesha Malik, Rayaz A Malik, Refref Yüksel, Faik Budak, Hamit Macit Selekler |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Cephalalgia. 43:033310242311708 |
| ISSN: | 1468-2982 0333-1024 |
| DOI: | 10.1177/03331024231170810 |
| Popis: | Background/Hypothesis Migraine affects >1 billion people but its pathophysiology remains poorly understood. Alterations in the trigeminovascular system play an important role. We have compared corneal nerve morphology in patients with migraine to healthy controls. Methods Sixty patients with episodic (n = 32) or chronic (n = 28) migraine and 20 age-matched healthy control subjects were studied cross-sectionally. Their migraine characteristics and signs and symptoms of dry eyes were assessed. Manual and automated quantification of corneal nerves was undertaken by corneal confocal microscopy. Results In patients with migraine compared to controls, manual corneal nerve fiber density (P 2 = 0.14, partial r = −0.37, P = 0.004) in patients with migraine. Conclusions Corneal confocal microscopy reveals corneal nerve loss in patients with migraine. It may serve as an objective imaging biomarker of neurodegeneration in migraine. |
| Databáze: | OpenAIRE |
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