The loss of left atrial contractile function predicts worse outcome in HFrEF: a speckle tracking study
| Autor: | Maria Concetta Pastore, Marta Focardi, Giulia Elena Mandoli, Serafina Valente, Sergio Mondillo, Martina Setti, Matteo Cameli, Giovanni Benfari, F D\\'ascenzi, C Carrucola, Mariangela Vigna, Luca Maritan |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | European Heart Journal - Cardiovascular Imaging. 22 |
| ISSN: | 2047-2412 2047-2404 |
| DOI: | 10.1093/ehjci/jeaa356.179 |
| Popis: | Funding Acknowledgements Type of funding sources: None. Background in chronic heart failure (HF), high cardiac pressure induces a progressive remodeling of small pulmonary arteries up to pulmonary hypertension development. At the end of left atrial (LA) conduit function, pulmonary and left heart end-systolic pressures equalize. This might affect LA systole. Purpose we investigated whether peak atrial contraction strain (PACS), measured by speckle tracking echocardiography (STE), was independently associated with outcome in HF with reduced ejection fraction(HFrEF). Methods 168 outpatients with HFrEF and sinus-rhythm referred to our echo-labs were prospectively enrolled. After clinical and echocardiographic evaluation, off-line STE analysis was performed. The endpoints were cardiovascular (CV) death and HF hospitalization respectively. Spline knotted survival model identified the optimal cut-off value for PACS. Results The 152 included patients were stratified based on PACS Conclusions The reduction of PACS significantly and independently affects CV outcome in HFrEF. Although limited to patients with sinus rhythm, it could offer additive prognostic information for HFrEF patients. Table 1 Variable PACS < 8 PACS ≥ 8 P value Age 61.5± 11.4 61.8 ± 12.7 0.4 NYHA class >2 26% (n = 39) 11% (n = 17) |
| Databáze: | OpenAIRE |
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