Immunologic Activation Parameters in Behçet's Disease
| Autor: | Neval Bayazıt, Mediha Yılmaz, Barbaros Oral, Necdet Tokgöz, Ali Yücel, Hayriye Sarıcaoğlu, Şükran Tunalı |
|---|---|
| Jazyk: | turečtina |
| Rok vydání: | 2008 |
| Předmět: | |
| Zdroj: | Turk Dermatoloji Dergisi, Vol 2, Iss 2, Pp 34-38 (2008) |
| ISSN: | 1308-5255 1307-7635 |
| Popis: | Objective: Behçet's disease (BD) is a chronic, multisystemic vasculitis of unknown etiology. Specific criteria to assess the activity of the disease, which has a course with remissions and relapses, have not been found; thus the evaluation of the activity of the disease is mainly based on the clinical findings. Therefore, there is a need for laboratory markers that can be correlated with clinical activity. In this report, we aimed to research parameters that may be used as activation marker in BD. Methods: Expressions of CD3, CD4, CD8, CD19, HLA-DR, TCR gd, TCR ab, coexpressions of CD3/CD25, CD19/CD25, CD19/HLA-DR, CD3/TCR gd, TCR gd/CD25, TCR gd/CD40L, TCR gd/CD 69, CD3/ TCR ab, TCR ab/ CD25, TCR ab/ CD40L, and TCR ab/CD69 were evaluated in active and inactive Behçet's patients. CD4/CD8 ratio was calculated and compared between the two groups. Results: TCR gd was found to be 5.064±2.079% in the active group, whereas it was 8.347±3.771% in the inactive group; there was a statistically significant difference between these data (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|