New enamine derivatives of lapachol and biological activity

Autor:	OLIVEIRA MAILCAR F., LEMOS TELMA L.G., MATTOS MARCOS C. DE, SEGUNDO TACIANA A., SANTIAGO GILVANDETE M.P., BRAZ-FILHO RAIMUNDO
Jazyk:	angličtina
Rok vydání:	2002
Předmět:	lapachol enamine derivatives biological activities lcsh:Q lcsh:Science
Zdroj:	Anais da Academia Brasileira de Ciências, Vol 74, Iss 2, Pp 211-221 (2002)
ISSN:	1678-2690 0001-3765
Popis:	A convenient synthesis of the new enamine derivatives 2-(4-morpholinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione, 2-(1-piperidinyl)-3-(3-methyl-2-butenyl)-1,4-naphtalenedione and 2-(1-pyrrolidinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione was carried out from natural 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthalenedione (lapachol) and morpholine, piperidine and pyrrolidine. The structures of the products were established mainly by NMR analysis, including 2D experiments. Biological activities of these products were evaluated against Artemia salina, Aedes aegypti and cytotoxicity using A549 human breast cells.
Databáze:	OpenAIRE
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