| Popis: |
The aim of this study is characterization and determination of critical micelle concentration of a novel lipid based system with Cisplatin by surface tension method. Surfactant solutions which are prepared by different concentrations, could show rapid changes of its osmotic pressure, conductivity, turbidity and surface tension at higher concentrations. McBain associated these rapid changes with the formation of micelles or aggregates. Critical micelle concentration (CMC) is defined as the concentration of surfactants above which micelles form and all additional surfactants added to the system go to micelles. There are several methods to measure the surface tension such as Wilhelmy plate, capillary rise method, drop weight method. In this study Traube Stalogmometer is used for drop weight method. Water, HCl buffer with pH 1,2 and phosphate buffer with pH 6,8 were used as solvents. CMC of Cisplatin containing lipid based system was found 0,0012 g/mL for each solvent. |
