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Hongyu Zhao,1* Rui Wang2* 1Central Laboratory, The Second Affiliated Hospital of Southeast University, Nanjing, People’s Republic of China; 2Nanjing Kingmed Clinical Laboratory Co., Ltd, Nanjing, People’s Republic of China *These authors contributed equally tothis work Background: Accumulated studies have evaluated the association of pre-miR-218 rs11134527 polymorphism with cancer risk in Chinese population. However, the results remain controversial.Methods: To derive a more precise and more comprehensive estimation of the relationship, six studies focused on Chinese population were included for the pooled analysis for pre-miR-218 rs11134527 polymorphism using odds ratios (ORs) with 95% confidence intervals (CIs). Results: Pre-miR-218 rs11134527 polymorphism was associated with cancer risk (G versusA, OR =0.93, 95% CI: 0.88–0.98; GG versus AG + AA, OR =0.88, 95% CI: 0.79–0.97; GG versusAA, OR =0.85, 95% CI: 0.76–0.96). In the stratified analysis by cancer type, the pre-miR-218 rs11134527 polymorphism was only associated with the risk of cervical cancer (G versusA, OR =0.90, 95% CI: 0.83–0.98; GG versus AG + AA, OR =0.80, 95% CI: 0.68–0.94; GG versus AA, OR =0.79, 95% CI: 0.66–0.94). Conclusion: These findings suggest that the pre-miR-218 rs11134527 genetic polymorphism may decrease the susceptibility to cervical cancer, which needs to be verified or linked with functional studies. Keywords: single-nucleotide polymorphisms, meta-analysis, polymorphism, cancer, risk |
