| Popis: |
Aim: The aim of this study was to evaluate erythrocyte sedimentation rate (ESR), high sensitivity C-reactive protein (hsCRP), neutrophil-to-lymphocyte ratio (NLR), monocyte to HDL-C ratio (MHR), and bilirubin levels in patients with migraine and compare with levels measured in healthy subjects. Methods: This retrospective case-control study included 136 migraine patients and 80 healthy controls who were admitted to our neurology outpatient clinic or emergency between June 2017 and June 2018. Laboratory examinations, disease characteristics, presence of aura, and the presence of white matter hyperintensities (WMHs) were recorded and demographic features and laboratory data were compared between two groups.Results: The mean age of the case group was 36.9 ± 10.6 years and the control group was 37 ± 12 years. In the patient group, total bilirubin, direct bilirubin, indirect bilirubin, and lymphocyte values were significantly lower than the control group. NLR, hsCRP, and ESR levels were significantly higher in the patient group than the control group. The patient and control groups did not show a significant difference according to the presence of WMHs. In the group with aura, monocyte and MHR values were higher than those without aura. The hsCRP values in the group with aura were significantly lower than the group without aura. Conclusion: This study showed that low bilirubin and high NLR, MHR, hsCRP, and ESR values might be potential inflammatory markers in migraine patients. These markers may contribute to our understanding of the pathophysiology of migraine. Since the cost of these tests is cheap and they are widely used, it is possible to believe that they may be useful for protecting migraine patients against long-term comorbidities. |
