Effect of Ochratoxin A and Aristolochic Acid on a Porcine Kidney Cell Line

Autor:	Daniela E Marin, Gina C Pistol, Ionelia Taranu
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	lcsh:Agriculture lcsh:T lcsh:S lcsh:Q lcsh:Science ochratoxin a aristolochic acid llc-pk cytokines lcsh:Technology
Zdroj:	Scientific Papers Animal Science and Biotechnologies, Vol 50, Iss 2, Pp 11-15 (2017)
ISSN:	2344-4576 1841-9364
Popis:	The Balkan endemic nephropathy (BEN) is an irreversible, chronic, tubulo-interstitial nephropathy described so far in several rural regions from the Balkan with an unknown aetiology. Both ochratoxin A (OTA) and aristolochic acid (AA) are considered responsible for BEN. This paper performed a comparison between the toxic effect of OTA and AA using a kidney cell line LLC-PK. OTA and AA decreased cell viability in a dose dependent manner. The dose dependent effect was observed for both toxins, the doses higher than 5mg/mL inducing a significant inhibition of viability (P
Databáze:	OpenAIRE
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