Comparison of concurrent chemoradiotherapy followed by radical surgery and high-dose-rate intracavitary brachytherapy: a retrospective study of 240 patients with FIGO stage IIB cervical carcinoma

Autor: Wang N, Li WW, Li JP, Liu JY, Zhou YC, Zhang Y, Hu J, Huang YH, Chen Y, Wei LC, Shi M
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: OncoTargets and Therapy, Vol 2014, Iss default, Pp 91-100 (2014)
ISSN: 1178-6930
Popis: Ning Wang,1 Wei-Wei Li,1 Jian-Ping Li,1 Juan-Yue Liu,1 Yong-Chun Zhou,1 Ying Zhang,1 Jing Hu,1 Yan-Hong Huang,2 Yan Chen,3 Li-Chun Wei,1,* Mei Shi1,*1Department of Radiation Oncology, 2Department of Gynecology and Obstetrics, 3Department of Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an, People's Republic of China *These authors both contributed equallyBackground: The aim of this study was to compare the long-term survival outcome and late toxicity in patients with FIGO (International Federation of Gynecology and Obstetrics) stage IIB cervical carcinoma after two treatment modalities, ie, concurrent chemoradiotherapy followed by radical surgery and concurrent chemoradiotherapy followed by high-dose-rate intracavitary brachytherapy.Methods: Between November 2004 and November 2011, 240 patients with FIGO stage IIB cervical carcinoma were analyzed, comprising 119 patients treated with concurrent chemoradiotherapy followed by radical surgery (group 1) and 121 patients treated with concurrent chemoradiotherapy followed by high-dose-rate intracavitary brachytherapy (group 2). Local control, overall survival, progression-free survival, and treatment-related complications were compared between the two groups.Results: The median follow-up duration was 36 months. Concurrent chemoradiotherapy followed by radical surgery showed a survival benefit when comparing group 1 and group 2 (3-year overall survival, 94.9% versus 84.6%, P=0.011; 3-year progression-free survival, 91.0% versus 81.8%, P=0.049, respectively). Three-year local pelvic control was 94.6% in group 1 and 93.3% in group 2 (P=0.325). Prognostic factors in group 1 were: age (≤35 years versus >35 years), 3-year progression-free survival (74.1% versus 90.9%, P=0.037); tumor diameter (≥6 cm versus
Databáze: OpenAIRE