| Autor: |
Chun-rong LIANG, Yu-hui LIU, Ye-ran WANG, Fan ZENG, Xin WANG, Hong-yuan CAO, Xu YI, Juan XU, Xiuqing YAO, Chang-yue GAO, Li-li ZHANG, Zhi-qiang XU, Lin WANG, Hua-dong ZHOU, Yan-jiang WANG |
| Jazyk: |
čínština |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Medical Journal of Chinese People's Liberation Army, Vol 39, Iss 2, Pp 133-137 (2014) |
| ISSN: |
0577-7402 |
| Popis: |
Objective To investigate the serum levels of inflammatory cytokines IL-6, IL-1β, TNF-α and IFN-γ, and explore the correlation between the inflammatory factor levels and the cognitive function in patients with Alzheimer's disease (AD). Methods One hundred and ten AD patients and 120 cognitively normal subjects were recruited in the present study. Serum levels of IL-6, IL-1β, TNF-α and IFN-γ were determined with enzyme-linked immunosorbent assay (ELISA). Mini-Mental State Examination (MMSE) and Clinical Dementia Rating Scale (CDR) were used to assess the cognitive function and activities of day living of the subjects. Wilcoxon rank sum test was used to compare the inflammatory cytokine levels between AD patients and healthy controls. Non-conditional logistic regression model was used to screen the potential influence factors of AD. Partial correlation analysis was performed to study the correlation between inflammatory cytokine levels of all subjects and MMSE scores in the whole sample, and the correlation between the serum levels of inflammatory cytokines and CDR scores was examined in the AD cohort. Results The serum levels of IL-1β (129.46 vs 102.70, P=0.002) and IL-6 (125.25 vs 106.56, P=0.033) were significantly higher in AD patients than that of normal control, while the values of TNF-α (116.40 vs 114.67, P=0.844) and IFN-γ (115.90 vs 115.14, P=0.931) were not significantly different between the two groups. The serum levels of IL-1β was correlated with MMSE score (r=–0.184, P=0.007) in the whole sample. No significant correlation was observed between serum inflammatory factors and CDR scores in AD patients. IL-1β was identified as a risk factor (OR=1.018, 95%CI 1.005-1.030), and duration of receiving education as a protective factor (OR=0.891, 95%CI 0.834-0.953) for AD. Conclusion The serum levels of inflammatory factors may be correlated with the cognitive function but not with the severity of dementia in AD patients. DOI: 10.11855/j.issn.0577-7402.2014.02.11 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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